Quarantine, Isolation and law, all three components working together since the emergence of COVID-19 pandemic .It is highly contagious disease spreads worldwide. To take a strictest action becoming mandatory and necessarily for every nation by keeping in view it’s alarming rapidly spreading situation. As this COVID-19, first highlighted in china wet market located at wuhan. It spreads from human to human and as travelers are more prone to hit by pandemic and potentially spread to others by becoming infected by it .So many countries first ban travelling and movement of people from one place to another. Those having recent travelling history need to be to put in isolation if found with any of symptom and their family members or dear ones with whom they were in contact after coming generally be quarantined. To make it successful various laws implemented in their respective countries. In this paper, we will highlight briefly the law, quarantine and isolation how made in sync or impactful in dealing such epidemic globally time to time. India’s Central Government and state governments are empowered to regulate health-related matters.  The Epidemic Diseases Act is the main legislative framework at the central level for the prevention and spread of dangerous epidemic diseases.  The Act empowers the central government to take necessary measures to deal with dangerous epidemic disease at ports of entry and exit.  The Act also empowers the states to take special measures or promulgate regulations to deal with epidemics within their state jurisdictions.  In such emergencies the states delegate some of these powers to the deputy commissioners in the districts, typically through state health acts or municipal corporation acts.  Thus, responsibility for directly addressing the crisis rests with the deputy commissioner at the district level.