Emulgel-Based Delivery of Phytoconstituents: Formulation, Characterisation and Stability

Abstract

Phytoconstituents are biological compounds with various therapeutic potentials, but these compounds have poor solubility and very low skin permeability. These factors, especially in topical delivery, affect the bioavailability of the agent and thereby reduce its pharmacological activities. These challenges can be overcome by formulating a drug delivery system that would increase its solubility. One such drug delivery system is emulgel. Emulgels can combine the properties of both emulsions and gels, providing an effective system for delivering lipophilic plant-derived compounds. This system can improve the stability of the drug and facilitate its penetration through the skin. Strong evidences support the enhanced delivery and improved therapeutic effectiveness of phytoconstituents like curcumin, quercetic and thymoquinone, especially in several conditions. Overall, emulgels represent a promising approach that bridges traditional phytotherapy with modern pharmaceutical technology, supporting the development of more effective topical treatments.