Effect of Aqueous Extracts of Some Indigenous Plants on Hematological Parameters, Hepatotoxicity and Antioxidant Status of Swiss Albino Rats Exposed to Cement Dust

Abstract

Exposure to cement dust can lead to respiratory problems, lung diseases, and even cancer. The study focuses on four plants: Telfaria occidentalis, Moringa oleifera, Zingiber officinale, and Hibiscus sabdariffa. These plants have been traditionally used for therapeutic purposes and are known for their potential health benefits. The study uses laboratory rats to assess the effects of these plants on hematological parameters and oxidative stress resulting from long-term exposure to cement dust. The results of the study show that the dietary supplements containing these plants have positive effects on hematological parameters, such as packed cell volume (PCV), red blood cell (RBC) count, and white blood cell (WBC) count. The extracts increase PCV levels, improve RBC production, and enhance immune system function. The study also finds that the supplements have antioxidant effects, as they increase the activity of antioxidant enzymes, such as catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH). Additionally, the supplements have positive effects on liver function markers, reducing the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In conclusion, the study suggests that dietary supplements containing Telfaria occidentalis, Moringa oleifera, Zingiber officinale, and Hibiscus sabdariffa have shown potential for mitigating the negative effects of cement dust pollution on hematological parameters, oxidative stress, and liver function. Further research is needed to understand the protective mechanisms of these plants and develop interventions to protect against industrial contaminants like cement dust.