ABOUT US
JOURNALS
ANNUAL SUBSCRIPTION
OUR TEAM
Join Us

Bulletin of Pure and Applied Sciences-Zoology (Started in 1982)
eISSN:2320-3188
pISSN: 0970-0765
Impact Factor: 5.395 (2017)
DOI: 10.5958/2320-3188
Editor-in-Chief:  Dr. Sushil Kumar Upadhyay
About Journal More Archive Visit IndianJournals.com
Current Issue
Archive
Guide for Authors
Journal's Ethics & Policies
Editorial Board
Reviewer Board
Indexing
UGC Protocol Part 1
UGC Approved Journal (Indexed in Web of Science )
Article Details

Bulletin of Pure and Applied Sciences-Zoology (Started in 1982)
Year : 2021, Volume & Issue : BPAS-Zoology 40A(2), JUL-DEC 2021
Page No. : 324-333, Article Type : Original Aticle
Article DOI : 10.5958/2320-3188.2021.00038.3 Article Info: Received on 04.09.2021 Accepted on 24.11.2021 Published on 15.12.2021

Hyperleptinemia is correlated with Metabolic Syndrome Risk Factors in Women with Polycystic Ovarian Syndrome

Zeinab Naghshband1, *Suttur S Malini2
Author’s Affiliation : 1PhD Research Scholar, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysuru, Karnataka 570006, India E-mail: [email protected] 2Professor and Chairperson, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysuru, Karnataka 570006, India E-mail: [email protected]

Corresponding Author : Suttur S Malini, Professor and Chairperson, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysuru, Karnataka 570006, India,
E-Mail:-[email protected]


Abstract

Polycystic ovarian syndrome (PCOS) as a common cause of anovulatory, is associated with glucose metabolic abnormality, hyperinsulinemia and obesity, features which are related to leptin and its receptors. However, there is still debate over the link between leptin and endocrine and metabolic factors in PCOS. The present study aim to compare both obese/overweight and normal/underweight PCOS and healthy women regarding anthropometric and endocrine parameters. Also, estimate inter-relationship of serum leptin levels with anthropometric and endocrine parameters. This is a case-control study including 150 PCOS women and 100 control subjects. Anthropometric indices were measured for each subject.  Lipid profile, fasting glucose, insulin, gonadotropin hormones, testosterone and serum leptin were estimated. Insulin resistance through HOMA-IR model and insulin sensitivity through (QUICKI) were calculated. Students t-test and two-way ANOVA were used for analyzing the differences between groups. Pearson (r) correlation coefficient was used to assess the correlation between serum leptin and the independent variables. Waist circumference was increased in normal/underweight PCOS group compared to normal/underweight control group. Fasting glucose and insulin, HOMA-IR, QUICKI and serum leptin levels were significantly increased in obese/overweight PCOS group compared to obese/overweight control group. Strong significant correlation was observed between serum leptin levels and increased BMI, LDL, fasting glucose, fasting insulin, HOMA-IR and hypotension. Serum leptin levels showed strong correlation with metabolic syndrome risk factors especially glucose metabolic abnormality in PCOS women compared to control.

Keywords

Polycystic Ovary Syndrome; LeptinSerum, Metabolic Syndrome, Anthropometric Indices, Endocrine Parameters
Download Now

(Only for authors and members not for commercial sale)

 

All rights reserved. Website Designed and Maintained by LASERWEBMAKER.COM

Publisher Ethics & Policies    |Downloads    |    Article Submission   |    Payment    |    Contact Us