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Bulletin of Pure and Applied Sciences-Zoology (Started in 1982)
eISSN:2320-3188
pISSN: 0970-0765
Impact Factor: 6.994 (Cosmos)
DOI: 10.5958/2320-3188
Editor-in-Chief:  Prof. Dr. Vineeta Shukla
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Article Details

Bulletin of Pure and Applied Sciences-Zoology (Started in 1982)
Year : 2022, Volume & Issue : BPAS-Zoology 41A(1), JAN-JUN 2022
Page No. : 120-124, Article Type : Original Aticle
Article DOI : 10.5958/2320-3188.2022.00015.8 Article Info: Received on 30.11.2021 Revised on 29.04.2022 Accepted on 15.05.2022 Published on 15.06.2022

Study of the Effect of Hypothyroidism and Thyrotoxicosis on the Proliferative Activity of the Red Bone Marrow in Experimental Animals with an Implanted Akatol Tumor

M.A. Ismayilova
Author’s Affiliation : Samarkand State University, Samarkand, Uzbekistan

Corresponding Author : M.A. Ismayilova Samarkand State University, Samarkand, Uzbekistan,
E-Mail:-bbozorov@samdu.uz


Abstract

Analysis of the morphological structure of histological preparations of the thymus of experimental animals showed that experimental hypothyroidism leads to significant rearrangements both in the cellular composition and in the structure of the organ. The absolute area of ​​the cortical zone, in comparison with the control group, significantly decreases, signs of hypertrophy of epithelial cells and an increase in the intensity of intracellular differentiation processes are revealed. There is little or no tissue proliferation. The proportion of lymphocytes in the cortical zone is 65.26±1.50%, the proportion of epithelial cells is 2.1±0.45%, which is significantly lower than those in the control group IV–81.45±1.22% and 4.2±0.63%, respectively. There are areas of rarefaction and degradation of the thymus tissue, which demonstrates the high rate of involutional processes. The thymus sharply decreased in size relative to the control and was represented by two small lobes and fragments, or was divided into separate segments, often of an irregular shape.

How to cite this article: Ismayilova M.A.  (2022). Study of the Effect of Hypothyroidism and Thyrotoxicosis on the Proliferative Activity of the Red Bone Marrow in Experimental Animals with an Implanted Akatol Tumor. Bulletin of Pure and Applied Sciences-Zoology, 41A (1), 120-124.

Keywords

Tumor strain of colon adenocarcinoma AKATOL, Red Bone Marrow, Thyroid Hormones, Apoptosis, Hypothyroidism, Thyrotoxicosis, BALB /c mice with implanted AKATOL tumor.
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