INSIGHTS OF SICKLE CELL ANEMIA; CROSS SECTIONAL STUDY FROM AKOLA DISTRICT MAHARASHTRA

Abstract

The blood contains several different types of cells. Each of these cell types is quite distinct in appearance, and each has a specific biologic function. Sickle cell disorder is a group of diseases caused by a point mutation at sixth position in beta Globin chain, Valine substituting Glutamic acid due to which in deoxygenated state, shape of erythrocytes change to sickle shape and also the fragility of cell membrane increases. Sickle cell anemia is a genetic disorder affecting haemoglobin the oxygen-transporting protein in red blood cells. Present study aims to Document Haematological profile of sickle cell anaemic subjects and Variation in pattern of haematological profile in HB-As and In HBSS subjects from Akola district of Maharashtra (India). In these findings we studied, 24 carriers Hb-AS and 7sufferer Hb-SS subjects for complete blood count.  Red Blood Cell count, (Hb-AS- 2.5559 ± 2.1422, Hb-SS- 2.4186 ± 1.5875, p < 0.0001) MCV (Hb-AS – in Hb-AS was 59.805 ± 19.813, and in Hb-SS was 71.643± 34.067, p < 0.0001) and HCT (47.191 ± 64.301 in AS, 22.1071 ± 12.6643 in SS patients), WBC count in present study 9.1436 ± 5.3290 in AS and in SS 10.2686 ± 4.4474 which differed statistically showing decreased level of haematological indices.