In-Silico Analysis of FANCD2 mutations presents in the FANCD2 protein MLS and their subsequent impacts

Abstract

The Fanconi Anemia complement protein plays a significant role in fixing the damage caused by nuclear intercross links in DNA. The in-silico analysis of the Fanconi anemia complement protein D2's unique mitochondrial localization signal sequence at the N-terminal of D2, which is 30 AA long, reveals the crucial steps of this FANCD2 activation through the addition of a single ubiquitin unit. An important role of FANCD2 in mitochondria is established by the cosmic database analysis of the 30 AA residues of MLS. Different cancer types develop in response to mutations within MLS.