Screening of Spider Venom Peptides and Molecular Docking of FLT3 and LCK

Abstract

The drawbacks of traditional chemotherapy include its inability to dissolve in water, lack of selectivity, and multidrug resistance. The use of anticancer peptides is a unique therapeutic approach against cancer cells. In this In-silico work, the kinase inhibition activity for both chosen target molecules (Flt3 and Lck protein) was evaluated in order to find a possible anti-leukemic spider venom peptide. Out of the 11 spider venom peptides, Lycosin-I peptide (from Lycosa singoriensis) for Lck and Latarcin 2a peptide (from Lachesana tarabaevi) for Flt3 were suggested as the best lead peptides for the creation of anti-leukemic drugs.