In vitro Antitubercular Activity of Dihydropyridine-Dicarboxamide and Pyrazole Derivatives against Mycobacterium tuberculosis

Abstract

The 1,4-dihydropyridine (DHP) is the most feasible heterocyclic ring with various substitutions at several positions. The DHP and pyrazole are ever-growing due to their varied biological, pharmaceutical and therapeutic applications. The antitubercular activity of some DHP and pyrozole derivatives (BPD, CMBPD, NMBPD, DPD, DNDDP, DMDDP, BEMPMP, OMEMPMP, KPEMPMP, CEMTDP and NEPMCP) have been documented in the present study. The in vitro activity of selected compounds as antitubercular agents have been measured in term of zone of inhibition (ZI) and minimum inhibitory concentration value (MIC, MIC50 and MIC90). The compounds BPD, DNDDP, CEMTDP, NEPMCP showed good antitubercular activity against Mycobacterium tuberculosis with zone of inhibition 20-21mm and MIC value ranged between 5-12. The other derivatives DPD, CMBPD, OMEMPMP demonstrated moderate antitubercular activity against M. tuberculosis with zone of inhibition 14 to 17mm with MIC value 10 to 14. However, compounds NMBPD, DMDDP showed remarkable antitubercular activity against M. tuberculosis with zone of inhibition 21mm and MIC value 4-5. While the compounds BEMPMP, KPEMPMP showed mild activity against M. tuberculosis with zone of inhibition 11-12mm and MIC value between 17 20.