The Automatic Identification Of Cancer Cell Drug Sensitivity: A New Model Based On Regression-Based Ensemble Convolution Neural Networks

Abstract

In line with recent advances in neural drug design and sensitivity prediction, we introduce a novel architecture for the interpretable prediction of anticancer compound sensitivity utilizing a multimodal attention-based convolutional encoder. Our approach is based on three primary foundations: prior knowledge of intracellular interactions from protein-protein interaction networks, gene expression profiles of tumors, and the structure of chemicals as a SMILES sequence. With R2 = 0.86 and RMSE = 0.89, our multi-scale convolutional attention-based encoder significantly outperforms a baseline model trained on Morgan fingerprints, a set of SMILES-based encoders, and the previously reported state-of-the-art for multimodal drug sensitivity prediction. Talk about the Ensemble Convolution Neural Network Model: A Novel Regression-Based Approach (ECNN-NRNN) to Drug Sensitivity Analysis Using Multiple Pharmaomics Data Sets and Addressing Heterogeneity in Feature Selection for Sub-Pharmacoomics Parameters. Because some pharmacogenomic data is available online and should be made publicly available, it is essential to address drug sensitivity prediction and drug identification and design. Outline how the performance in sensitivity prediction can be improved using conventional methods, and provide an experimental evaluation.