Synthesis Of Dehydro- And Oxohomoproaporphine Alkaloids

Abstract

In the last decade, from a large number of plants - producers of aporphine alkaloids and analogues, their dehydro derivatives containing double bonds and hydroxy groups in various positions have been isolated [1] and their quaternary bases were also synthesized.

Cava and others [2] iodine oxidation of non-phenolic aporphins converted them into 6a,7-dehydro and 7-oxoaporphins, while iodine oxidation of phenolic aporphins led to completely different compounds [3]. Thus, in the oxidation of isotebaine (1) with iodine, compound 2 was isolated in green.