"Enhanced Periapical Bone Regeneration Using Recombinant Human Platelet-Derived Growth Factor And Beta-Tricalcium Phosphate: A Case Series"

Abstract

The objective of this study was to evaluate the efficacy of recombinant human platelet-derived growth factor (rhPDGF) combined with beta tricalcium phosphate (β-TCP) in promoting the regeneration of periapical bone following periapical surgery. A case series was conducted involving patients who underwent periapical surgery, where the bone defect was treated with a graft composed of rhPDGF-BB and β-TCP. The patients were monitored over a 6-month follow-up period, during which clinical and radiographic evaluations were performed to assess the extent of bone regeneration. Results indicated significant bone regeneration in the treated sites, with almost complete restoration of the periapical bone observed at the 6-month mark. These findings suggest that the combination of rhPDGF and β-TCP is a promising biomaterial for enhancing periapical bone regeneration following endodontic surgery. Further studies with larger sample sizes and longer follow-up periods are recommended to confirm these results.