Clinical Efficacy of Mulethi (Glycyrrhiza glabra) Gel in the Management of Localized Aggressive Periodontitis: A Randomized Controlled Trial

Abstract

Background: Localized Aggressive Periodontitis (LAP) is a severe periodontal condition that requires effective intervention to prevent progression. Natural products like Mulethi (Glycyrrhiza glabra) have demonstrated anti-inflammatory and antimicrobial properties, making them potential adjunctive therapies in periodontal treatment.

Objective: To evaluate the clinical efficacy of Mulethi gel as an adjunctive treatment for Localized Aggressive Periodontitis.

Methods: A randomized controlled trial was conducted with 60 participants diagnosed with LAP, divided into two groups: the test group (n=30) treated with Mulethi gel and scaling and root planing (SRP) and the control group (n=30) treated with SRP alone. Clinical parameters including Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), and Gingival Index (GI) were assessed at baseline, 3 months, and 6 months post-treatment. Statistical analysis was performed using SPSS 25.0 version.

Results: The test group showed a significant reduction in PPD and improvement in CAL and GI scores compared to the control group at both 3 and 6 months (p<0.05). Mulethi gel, as an adjunct to SRP, significantly enhanced clinical outcomes, demonstrating its effectiveness in managing LAP.

Conclusion: Mulethi gel is a promising adjunctive therapy for LAP management, showing significant improvements in periodontal health outcomes. Further long-term studies are required to validate these findings and assess the long-term sustainability of the results.