A Composition of Phyllanthus Niruri Extract for Antioxidant and Hepatoprotective Benefits in Hepatitis B

Abstract

 Hepatitis B Virus (HBV) remains a significant global health challenge, leading to severe liver complications, including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).” Current antiviral therapies face limitations such as incomplete viral suppression and adverse effects, prompting interest in alternative treatments. Phyllanthus niruri, a medicinal plant recognized for its antioxidant, hepatoprotective, and antiviral properties, offers a promising adjunct therapy for HBV management. This study evaluated the phytochemical composition, antioxidant potential, hepatoprotective effects, and antiviral efficacy of Phyllanthus niruri. Key bioactive compounds, including flavonoids, lignans, and tannins, were identified, contributing to its therapeutic effects. Biochemical and histopathological analyses demonstrated significant improvements in liver enzyme levels, antioxidant enzyme activity, and fibrosis reduction, with a 60% decrease in HBV DNA levels observed. Comparative analysis with lamivudine revealed comparable antiviral efficacy, with additional benefits in oxidative stress reduction and liver regeneration. These findings highlight Phyllanthus niruri as a holistic, natural therapy for HBV, warranting further clinical validation.