A Systematic Review of Citrus Medica Leaves

Abstract

This systematic review examines the current state of knowledge regarding Citrus medica leaves, focusing on their botanical characteristics, phytochemical composition, and potential therapeutic applications. A comprehensive literature search was conducted across multiple databases, yielding studies that met predefined inclusion criteria. The review highlights the rich phytochemical profile of Citrus medica leaves, including essential oils, flavonoids, and phenolic compounds, which contribute to their diverse pharmacological properties. Notable among these are antioxidant, anti- inflammatory, and antimicrobial activities, suggesting potential for various medicinal applications. Traditional uses of Citrus medica leaves in different cultures are explored, alongside modern research investigating their efficacy in treating various ailments. The review also addresses toxicological aspects, agricultural practices, and the environmental impact of Citrus medica cultivation. While the findings underscore the promising therapeutic potential of Citrus medica leaves, they also reveal significant gaps in current research, particularly in clinical studies and standardization of extracts. This review provides a foundation for future investigations and highlights the need for more robust clinical trials to fully elucidate the therapeutic value of Citrus medica leaves in modern medicine.